A multiomic single-cell landscape of human gynecologic malignancies

10x GENOMICS
4/27/22, 12:00 PM
America/Pacific Time UTC -8:00 / -7:00

Description

Deconvolution of regulatory mechanisms that drive transcriptional programs in cancer cells is key to understanding tumor biology. In this webcast, Hector Franco, Ph.D., assistant professor in the Department of Genetics at the University of North Carolina at Chapel Hill, will demonstrate his lab’s recent use of single-cell RNA sequencing and chromatin accessibility profiling as a way to unravel the regulatory logic of tumor cells and suggest novel avenues for targeted therapies.

 

Dr. Franco will present matched single-cell transcriptomic and epigenomic datasets from human ovarian and endometrial tumors, followed by a discussion of the resulting integrated data analysis aimed at defining the regulatory programs of cancer cells. This work highlights the importance of revealing intratumoral heterogeneity and previously unidentified regulatory elements that may represent new targets for therapeutic intervention.

 

You will:

  • Understand single-cell transcriptomic and epigenomic profiling of solid tumors
  • Associate changes in chromatin variation to transcriptional outputs
  • Identify and functionally annotate oncogenic-enhancer elements
  • Identify key transcription factors that drive gene expression programs in cancer cells
Previous registration necessary?

NO

YES
Simultaneous translation ?

NO

YES
Will it be recorded?
NO
YES

Sarah Hiddleston

A multiomic single-cell landscape of human gynecologic malignancies

Inglês

 

Speakers

Hector L. Franco

 

Link to the Event

Banner to the Event

A multiomic single-cell landscape of human gynecologic malignancies