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Webinar with winners of the EACR & Novosanis research grant: Part 1

novosanis, EACR
10/18/22, 1:00 PM
America/New York GMT -4 summer

Description

Early detection of ovarian cancer using aptamers in urine
Presenters: Dr. Anne-Cécile E. Duc and Antonija Hanžek

 

Ovarian cancer (OC) is the deadliest gynecological cancer. When it is diagnosed in early stages, 5-year survival of the disease is 90 %. Unfortunately, most of the cases are diagnosed in advanced stages of the disease with survival of only 15-40%. Due to the lack of specific symptoms and efficient diagnostic tools, OC is difficult to detect. Current diagnostic methods are invasive, consisting of a pelvic examination, transvaginal ultrasonography, and blood tests to detect cancer antigen 125 (CA125), often preventing women from testing early and easily. To improve detection and reduce the high death rate among OC patients, more efficient and non-invasive diagnostic tests are needed. Recently, single-stranded oligonucleotides called the aptamers have emerged as potential cancer detection tools due to their high-affinity, low cost and variability of application in diagnostics.

 

Among a wide spectrum of proteomic biomarkers, Human Epididymis protein 4 (HE4), protein overexpressed in OC, has shown to be very promising. As a single biomarker, it shows highest sensitivity and specificity for OC detection. Unlike CA125, HE4 is not overexpressed in benign ovarian diseases.

 

Moreover, urinary HE4 is extremely stable for longer periods of time compared to serum HE4 and CA125. Therefore, urine has become an interesting alternative source of HE4 for detection of OC.

 

In this webinar, Dr. Anne-Cécile E. Duc and Antonija Hanžek will highlight their research, focusing on early detection of ovarian cancers using aptamers in urine, focusing on HE4 protein, and the potential of Colli-Pee® as a self-sampling tool.

 

Liquid biopsy non-invasive: Colli-Pee, preservatives and application
Presenter: Stephanie Jordaens

 

Early detection of cancer can greatly increase chances of survival and improve the overall quality of life of a patient. Cancer biomarkers can be found in tissues as well as bodily fluids and can be used to detect disease early as well as monitor disease progression. A high number of potentially informative cancer biomarkers have been found in urine, including cfDNA, DNA, RNA, EV, proteins and metabolites.

 

However, to truly exploit the potential of urine as a liquid biopsy, optimal urine collection methods and storage conditions for biomarker detection are required. Colli-Pee® has shown to allow standardized volumetric collection and preservation of urine.

 

In her webinar, Stephanie Jordaens, will highlight the potential of urine in cancer research and monitoring, with a focus on prostate and breast cancer.

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Early detection of ovarian cancer using aptamers in urine, Liquid biopsy non-invasive: Colli-Pee, preservatives and application

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Speakers

Anne-Cécile E. Duc, Antonija Hanžek, Stephanie Jordaens

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