Targeting Oxygen Sensing in Cancer

bio-techne
America/Pacific Time UTC -8:00 / -7:00

Description

Low oxygen (hypoxia) is an emerging pathobiological hallmark of practically all solid tumors, acting as an independent prognostic factor in cancer patients. Canonically, hypoxia is transduced to the nucleus of cancer cells via hypoxia-inducible factor (HIF)- dependent transcriptional activation; however, recent evidence suggests that other HIF-independent pathways can complement or provide redundancy to these effects. We hereby discuss canonical and alternative oxygen sensing mechanisms implicated in therapy resistance and recurrence in cancer. In addition, we highlight recent evidence suggesting that conventional chemotherapy might act as an oxygen- independent HIF inducer in preclinical models of colon and breast cancer, thereby promoting therapy failure, metastasis and ultimately, mortality.

 

During the webinar, viewers will:

 

-Understand the current molecular oxygen-sensing framework in human cancer cells

-Hear a summary of the molecular and clinical implications of tumor hypoxia

-Explore recent evidence suggesting novel chemotherapeutic strategies targeting HIFs

-Have the opportunity to ask questions during the live broadcast

Raymond Chan

Hypoxia signaling in the tumor microenvironment, Hypoxia as a driver of cancer metastasis

Inglês

Previous registration necessary?

NO

YES
Simultaneous translation ?

NO

YES
Will it be recorded?
NO
YES
 

Speakers

Sergio Rey, Luana Schito

 

Link to the Event

Banner to the Event

Targeting Oxygen Sensing in Cancer
 
 
 

Download the Agenda

Search for our next event. See you soon!

Subscribe to get news on all upcoming events

who%20goals_edited.png

DocMeeetings

Social Media

  • Twitter DocMeetings
  • Instagram DocMeetings
  • Facebook ícone social
  • LinkedIn ícone social

contact us

Adress

Sao Paulo, SP - Brazil

© 2020 by Docmeetings - A DocMeetings.com Company
Site Managed by:
QUALITY Soluções Web
1996-2021 "25 years inspiring technology"