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In order to help patients make informed treatment decisions, health care professionals need to understand the clinical data regarding the efficacy and safety of newly approved regimens. In addition, toxicity management, particularly with the oral agents can pose a unique challenge to pharmacists, nurses, and physicians as well as patients and caregivers. The involvement of a multidisciplinary health care team is vital to ensure adequate safety monitoring and management of treatment-related adverse events. Pharmacists play a critical role in patient education, monitoring, and management of treatment-related toxicities and will benefit from a comprehensive review of the novel treatments for cutaneous melanoma.