The use of genetically modified mouse models and in vitro cell culture models for efficacy studies in immuno-oncology

Nexcelom, BIOCYTOGEN
America/New York GMT -4 summer

Description

Mouse models are an integral part of cancer research. Syngeneic tumor models and human immune cell-engrafted mice are two of the popular preclinical tools in immuno-oncology studies. During the first half of the webinar Dr. Frank An will discuss the following:

 

• Use of genetically humanized mice for antibody efficacy studies in mouse syngeneic cancer models.

• Use of severely immuno-deficient B-NDG mice to characterize human immune cells activities (T and NK cells).

 

In the second half of the webinar, Dr. Andrea Love will discuss challenges in immuno-oncology research and in vitro cell-based assays that can be used to overcome these. We will introduce image cytometry and how it is used to investigate therapeutic efficacy of cancer immunotherapies. We will review:

 

• Immune cell functional assays to assess viability, cell health, and cell proliferation

• Complex co-culture assays to measure specificity of immunotherapies

• Personalized organoid models for cell-mediated cytotoxicity

The use of genetically modified mouse models and in vitro cell culture models for efficacy studies in immuno-oncology

Inglês

Previous registration necessary?

NO

YES
Simultaneous translation ?

NO

YES
Will it be recorded?
NO
YES
 

Speakers

Frank An, Andrea C. Love

 

Link to the Event

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The use of genetically modified mouse models and in vitro cell culture models for efficacy studies in immuno-oncology
 
 
 

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